Sample patterning on NMR surface microcoils[EPFL]

mt7344

Abstract
5 d+ I/ j0 N( }  ]( L; G; O) OAligned microcontact printing for patterning the sample in areas of homogeneous RF-field on the highly sensitive surface of planar
NMR microprobes is presented. We experimentally demonstrate that sample patterning allows drastic improvement of the spin excitation
# V4 n5 ]$ N8 p% r3 O5 @; R0 ?uniformity. The NMR microprobes are designed for cell analysis and characterized using lipid vesicles as cell substitutes. Lipid vesicles
3 X% n1 w+ e( N4 Y0 A: e  ^8 B! j! Aare advantageous as composition and concentration of the confined solution are precisely controlled and because of their similarity
" a- B) {" H! U# @6 qto living cells. Using aligned microcontact printing, a monolayer of lipid vesicles is immobilized on the surface of the planar NMR microprobe
/ ]4 o2 {5 g* ?/ O. Tin a patterned way. 1H NMR spectra and CPMG spin echoes of sucrose solution confined within the lipid vesicles are successfully
0 Z5 M- N: }) ^: srecorded. Nutation curves of the sample structured in different patterns demonstrate the impact of patterning on the spin excitation uniformity.
5 P2 \+ O. J% f: p. I' |The total detection volumes are between 1 and 2 nL and derived with help of a theoretic model based on 3D finite element simulation.
This model predicts the signal-to-noise ratio and the progression of the nutation curves.
  ?8 g9 _+ [1 x( ~( v
2005 Elsevier Inc. All rights reserved.


# D! A9 }% z- N網路上抓的 paper, 希望對大家有幫助!!
權限10 & RDB=3
) F! g6 G6 m0 k0 O, ]
' B* g0 C- [( k- R9 e8 e

遊客，如果您要查看本帖隱藏內容請回復

3 \, M2 y/ i8 N) Z; r
[ 本帖最後由 mt7344 於 2007-6-7 10:38 PM 編輯 ]